@Herjan, for our character we’ve taken about eight hours to draw all the pieces. We’ve drawn the character only once, but it’s several heads, arms and legs to perform all necessary animations.
The time to complete an animation varies greatly depending on the animation. But we can do about 2 animations at day (with their different cycles, for example “Crouching” is divided into: Crouching, stand still crouched, crouch gait and Rise).
From what you say I guess you’re doing an RPG with top view. If all your characters have the same proportions, with Spine, you’d just animate the characters once and then create each character skins (You could even create a very cool customization system)
Check the Esoteric Software website and watch the videos. I think Spine can be useful for your project.