Nope, not at all. I find it simply too much work for a rather meager return. I know Abuse was big on disassembling and reassembing his code to get those sorts of gains, but I could never quite get into that. I’d much rather develop a technology to do it for me.
However, I do usually run a program like JoGa that not only strips out unnecesary info, but reduces necessary info to as little space as possible.