If small methods do not get properly inlined, then they CAN make trouble. In the case of a fractal drawing program, I wrote a class for manipulating complex numbers with methods for basic algebraic operations. The simple complex operation “z^2 + c” would involve two method calls. After hundreds of iterations, this is quite a lot of method calls, and it turned out that manually inlining these bits increased efficiency several times. The method bodies themselves were just two or three lines with a couple of multiplications and assignments.
I can’t imagine the horrors of further using getters and setters in that situation (which was, by the way, completely unnecessary since it all went on inside the class itself).